By Kenneth L. Rinehart, Jr. and Tetsuo Suami (Eds.)
content material: Aminocyclitol antibiotics : an creation / Kenneth L. Rinehart, Jr. and Lois S. defend --
Synthesis of aminocyclitol antibiotics / S. Umezawa --
amendment of aminocyclitol antibiotics / Tetsuo Suami --
Syntheses of some branched-chain aminocyclitol antibiotics / Juji Yoshimura, Masuo Funabashi, and Chung-Gi Shin --
a brand new synthesis of branched-chain epi-configuration deoxyhalogeno- and deoxyaminocyclitols / Donald E. Kiely and James M. Riordan --
The stereospecific synthesis of spectinomycin / D.R. White, R.D. Birkenmeyer, R.C. Thomas, S.A. Mizsak, and V.H. Wiley --
Synthesis of spectinomycin analogs / R.C. Thomas, D.R. White, V.H. Wiley, and D.A. Forster --
Spectinomycin amendment / W. Rosenbrook, Jr. and Ronald E. Carney --
The constructions of diastereomers of dihydrospectinomycins / Louise Foley and Manfred Weigele --
Chemical amendment of aminoglycosides : a singular synthesis of 6-deoxyaminoglycosides / Barney J. Magerlein --
The impression of O-methylation at the job of aminoglycosides / J.B. McAlpine, R.E. Carney, R.L. Devault, A.C. Sinclair, R.S. Egan, M. Cirovic, R. Stanaszek, and S. Mueller --
The synthesis and organic homes of 3'- and 4'-thiodeoxyneamines and 4'-thiodeoxykanamycin B / Thomas W. Ku, Robert D. Sitrin, David J. Cooper, John R.E. Hoover, and Jerry A. Weisbach --
Synthesis of analogs of kanamycin B / J.P.H. Verheyden, D.B. Repke, T.C. Tompkins, and J.G. Moffatt --
The selective N-acylation of kanamycin A / M.J. Cron, J.G. Keil, J.S. Lin, M.V. Ruggeri, and D. Walker --
Carbon-13 NMR spectra of aminoglycoside antibiotics / Takayuki Naito, Soichiro Toda, Susumu Nakagawa, and Hiroshi Kawaguchi --
The buildings of adlescent parts of the fortimicin advanced / J.B. McAlpine, R.S. Egan, R.S. Stanaszek, M. Cirovic, S.L. Mueller, R.E. Carney, P. Collum, E.E. Fager, A.W. Goldstein, D.J. Grampovnik, P. Kurath, J.R. Martin, G.G. submit, J.H. Seely, and J. Tadanier --
The constructions of recent fortimicins having double bonds of their purpurosamine moieties / Kunikatsu Shirahata, Gen Shimura, Seigo Takasawa, Takao Iida, and Keiichi Takahashi --
Enzymes editing aminocyclitol antibiotics and their roles in resistance decision and biosynthesis / Julian Davies --
Biosynthesis and mutasynthesis of aminocyclitol antibiotics / Kenneth L. Rinehart, Jr. --
Chemical and organic amendment of antibiotics of the gentamicin crew --
P.J.L. Daniels, D.F. Rane, S.W. McCombie, R.T. Testa, J.J. Wright, and T.L. Nagabhushan --
Synthesis and mutasynthesis of pseudosaccharides with regards to aminocyclitol-glycoside antibiotics / J. Cléophax, A. Roland, C. Colas, L. Castellanos, S.D. Géro, A.M. Sepulchre, and B. Quiclet --
a number of interactions of aminoglycoside antibiotics with ribosomes / Bernard D. Davis and Phang-C. Tai.
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Additional info for Aminocyclitol Antibiotics
And when 3 ,4'-di-O-acetyl-1,3,2 ,6 -tetrakis-N-(benzyloxycarbonyl)neamine was t r e a t e d w i t h a c e t i c anhydride i n p y r i d i n e i n a r e f r i g e r a t o r , 6-0-acetyl d e r i v a t i v e was obtained i n a f a i r l y good y i e l d ( 7 ) . 5-Deoxyneamine (R) can be prepared from the 6-0-acetyl d e r i v a t i v e . C h l o r i n a t i o n of compound J_ w i t h s u l f u r y l c h l o r i d e i n p y r i dine gave the corresponding 5-chloro-5-deoxy d e r i v a t i v e (P) as c r y s t a l s i n 64% y i e l d .
Jikihara, T . , Tsuchiya, T . , Umezawa, S. , Bull. Chem. Soc. , (1973), 46, 3507. 38. , Umezawa, H . , Okazaki, Y. and Tsuchiya, T . , Bull. Chem. Soc. , (1972), 45, 3624. 39. , Suzuki, T . , Tsuchiya, T . , Umezawa, S. , Bull. Chem. Soc. , (1973), 46, 3210. 40. , Tsuchiya, T . , Umezawa, S. , Bull. Chem. Soc. , (1974), 47, 3136. 41. Miyake, T . , Tsuchiya, T . , Umezawa, S. , Carbohyd. , (1976), 49, 141. 42. Woo, P. W. , Dion, H. W. and Bartz, Q. , (1971), 2625. 43. Kawaguchi, H . , Naito, T .
And Umezawa, H . , J. Antibiot. (Tokyo), (1976), 29, 978. 53. Sano, H . , Tsuchiya, T . , Umezawa, S. and Umezawa, H . , Bull. Chem. Soc. , (1977), 50, 975. 54. Yamasaki, T . , Tsuchiya, T. , J. Antibiot. (Tokyo), (1978), 31, 1233. 55. Tsuchiya, T . , Nakamura, F . , Usui, T . , Kitamura, M. , (1978), 3365. RECEIVED November 15, 1979. ch003 Department of Applied Chemistry, Faculty of Engineering, Keio University, Hiyoshi, Yokohama 223, Japan Chemical and biological modifications of aminocyclitol antibiotics have been extensively studied to elucidate a structure-antimicrobial activity relationship.