A Manual of Morphometry in Diagnostic Pathology by Jan P. A. Baak M.D., Ph.D., Jan Oort M.D., Ph.D. (auth.)

February 23, 2017 | Pathology | By admin | 0 Comments

By Jan P. A. Baak M.D., Ph.D., Jan Oort M.D., Ph.D. (auth.)

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Four sets of 10 (or 25 if required) high power fields should be counted and the maximum number in anyone set used. 5. Only definite mitotic figures should be counted, doubtful structures should be excluded. 14 where the number of mitotic figures is expressed per 1000 nuclei. At present, counting of mitotic figures is subjective. However, if the abovementioned criteria ;:lIe used and the measures mentioned are taken in counting mitotic figures, the "human" factor in causing discrepancies has largely been excluded, and a high reproducibility has been found (Baak et aI, 1982).

Computer-oriented approaches to pattern recognition. Mathematics in science and engineering, vol. 83, Academic Press, New York. E. (1978). Basic principles of ROC analyses. Semin. , 8, 283-298. G. P. (1980). The threshold approach to clinical decision making. N. Engl. J. Med. 302, 1109-1117. G. A. (1981). Nine-cell diagnostic decision matrix. Am. J. Clin. Pathol. 75, 769-772. I. G. (1981). Pathology and probabilities. A new approach to interpreting and reporting biopsies. N. Engl. I. Med. 305, 917-923.

4 Decision Rules Of course, the higher the efficiency, sensitivity, specificity and predictive value of a positive and negative result the better the diagnostic power of a certain feature. 2, single features often show a considerable overlap (hence misclassifications). The investigation and analysis of more than one feature may help to improve the distinction between different groups. The different features may then be arranged in a certain sequence, or combination, to discriminate between groups and to make a decision in a given case.

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